118 research outputs found
La discipline archivistique au Canada : Ă©tat de dĂ©veloppement et perspectives dâavenir
Aujourdâhui, au Canada comme ailleurs, lâarchivistique est devenue une profession, une discipline Ă part entiĂšre ayant droit de citĂ© dans les universitĂ©s, dans les cercles de recherche et dans la sociĂ©tĂ© en gĂ©nĂ©ral. Pour apprĂ©hender le chemin parcouru, il nây a quâĂ considĂ©rer le foisonnement dâĂ©crits â monographies, articles de revues professionnelles et scientifiques, recherches (rapports, mĂ©moires et thĂšses rĂ©alisĂ©s par les Ă©tudiants) â et dâĂ©vĂ©nements de toutes sortes (congrĂšs, colloques, confĂ©rences et ateliers) qui animent les communautĂ©s archivistiques locales, nationales et internationales. Tout cela dans un contexte oĂč le prĂ©sent et lâavenir de la discipline archivistique, au plan national et international, sont fortement touchĂ©s par la « dĂ©ferlante numĂ©rique » qui transforme et continuera de transformer de façon irrĂ©versible le quotidien de notre sociĂ©tĂ©. Si on nous demandait dâidentifier lâĂ©lĂ©ment le plus important du dĂ©veloppement quâa connu lâarchivistique au cours des derniĂšres annĂ©es et qui marquera le futur de cette discipline, les technologies de lâinformation et leur impact sur la gestion de lâinformation feraient assurĂ©ment lâunanimitĂ©.Today, in Canada as elsewhere, âarchival workâ has become a profession and a recognised discipline in universities, research services and society in general. To understand this evolution we have only to consider the profusion of papersâmonographs, articles in professional and scientific reviews, research papers (reports and theses written by students)âand for academic events of all kinds (congresses, colloquiums, conferences and workshops) which affect local, national and international archival communities. All this is taking place in a context where the present and future of archival disciplines, both nationally and internationally, are strongly affected by the tidal wave of digitisation which is transforming, and will continue to transform everyday life in society. If we were asked to identify the most important element in the recent developments witnessed by archival disciplines and which will mark the future of these disciplines, information technologies and their impact on information management would undoubtedly be the reply
Bots, Seeds and People: Web Archives as Infrastructure
The field of web archiving provides a unique mix of human and automated
agents collaborating to achieve the preservation of the web. Centuries old
theories of archival appraisal are being transplanted into the sociotechnical
environment of the World Wide Web with varying degrees of success. The work of
the archivist and bots in contact with the material of the web present a
distinctive and understudied CSCW shaped problem. To investigate this space we
conducted semi-structured interviews with archivists and technologists who were
directly involved in the selection of content from the web for archives. These
semi-structured interviews identified thematic areas that inform the appraisal
process in web archives, some of which are encoded in heuristics and
algorithms. Making the infrastructure of web archives legible to the archivist,
the automated agents and the future researcher is presented as a challenge to
the CSCW and archival community
Recent Progress in the Management of Retroperitoneal Sarcoma
Retroperitoneal sarcomas (RPS) are rare tumours that typically present late and carry a poor prognosis even following grossly complete resection. In an attempt to improve the outlook for patients with RPS, sarcoma specialists have employed various adjuvant therapies, including extermal beam radiation, intraoperative radiation, brachyradiation and systemic chemotherapy. This article reviews the presentation and prognosis of RPS, and focuses on the results of new treatment strategies compared with conventional management
Oxidative discolouration in whole-head and cut lettuce: biochemical and environmental influences on a complex phenotype and potential breeding strategies to improve shelf-life
Lettuce discolouration is a key post-harvest trait. The major enzyme controlling oxidative discolouration
has long been considered to be polyphenol oxidase (PPO) however, levels of PPO and subsequent development of discolouration symptoms have not always correlated. The predominance of a latent state of the enzyme in plant tissues combined with substrate activation and contemporaneous suicide inactivation
mechanisms are considered as potential explanations for
this phenomenon. Leaf tissue physical properties have
been associated with subsequent discolouration and
these may be influenced by variation in nutrient
availability, especially excess nitrogen and head maturity at harvest. Mild calcium and irrigation stress has
also been associated with a reduction in subsequent
discolouration, although excess irrigation has been
linked to increased discolouration potentially through
leaf physical properties. These environmental factors,
including high temperature and UV light intensities,
often have impacts on levels of phenolic compounds
linking the environmental responses to the biochemistry
of the PPO pathway. Breeding strategies targeting the
PALand PPOpathway biochemistry and environmental
response genes are discussed as a more cost-effective
method of mitigating oxidative discolouration then
either modified atmosphere packaging or post-harvest
treatments, although current understanding of the
biochemistry means that such programs are likely to
be limited in nature and it is likely that they will need to be deployed alongside other methods for the foreseeable future
Implicating genes, pleiotropy, and sexual dimorphism at blood lipid loci through multi-ancestry meta-analysis
Publisher Copyright: © 2022, The Author(s).Background: Genetic variants within nearly 1000 loci are known to contribute to modulation of blood lipid levels. However, the biological pathways underlying these associations are frequently unknown, limiting understanding of these findings and hindering downstream translational efforts such as drug target discovery. Results: To expand our understanding of the underlying biological pathways and mechanisms controlling blood lipid levels, we leverage a large multi-ancestry meta-analysis (N = 1,654,960) of blood lipids to prioritize putative causal genes for 2286 lipid associations using six gene prediction approaches. Using phenome-wide association (PheWAS) scans, we identify relationships of genetically predicted lipid levels to other diseases and conditions. We confirm known pleiotropic associations with cardiovascular phenotypes and determine novel associations, notably with cholelithiasis risk. We perform sex-stratified GWAS meta-analysis of lipid levels and show that 3â5% of autosomal lipid-associated loci demonstrate sex-biased effects. Finally, we report 21 novel lipid loci identified on the X chromosome. Many of the sex-biased autosomal and X chromosome lipid loci show pleiotropic associations with sex hormones, emphasizing the role of hormone regulation in lipid metabolism. Conclusions: Taken together, our findings provide insights into the biological mechanisms through which associated variants lead to altered lipid levels and potentially cardiovascular disease risk.Peer reviewe
Implicating genes, pleiotropy, and sexual dimorphism at blood lipid loci through multi-ancestry meta-analysis
Funding GMP, PN, and CW are supported by NHLBI R01HL127564. GMP and PN are supported by R01HL142711. AG acknowledge support from the Wellcome Trust (201543/B/16/Z), European Union Seventh Framework Programme FP7/2007â2013 under grant agreement no. HEALTH-F2-2013â601456 (CVGenes@Target) & the TriPartite Immunometabolism Consortium [TrIC]-Novo Nordisk Foundationâs Grant number NNF15CC0018486. JMM is supported by American Diabetes Association Innovative and Clinical Translational Award 1â19-ICTS-068. SR was supported by the Academy of Finland Center of Excellence in Complex Disease Genetics (Grant No 312062), the Finnish Foundation for Cardiovascular Research, the Sigrid Juselius Foundation, and University of Helsinki HiLIFE Fellow and Grand Challenge grants. EW was supported by the Finnish innovation fund Sitra (EW) and Finska LĂ€karesĂ€llskapet. CNS was supported by American Heart Association Postdoctoral Fellowships 15POST24470131 and 17POST33650016. Charles N Rotimi is supported by Z01HG200362. Zhe Wang, Michael H Preuss, and Ruth JF Loos are supported by R01HL142302. NJT is a Wellcome Trust Investigator (202802/Z/16/Z), is the PI of the Avon Longitudinal Study of Parents and Children (MRC & WT 217065/Z/19/Z), is supported by the University of Bristol NIHR Biomedical Research Centre (BRC-1215â2001) and the MRC Integrative Epidemiology Unit (MC_UU_00011), and works within the CRUK Integrative Cancer Epidemiology Programme (C18281/A19169). Ruth E Mitchell is a member of the MRC Integrative Epidemiology Unit at the University of Bristol funded by the MRC (MC_UU_00011/1). Simon Haworth is supported by the UK National Institute for Health Research Academic Clinical Fellowship. Paul S. de Vries was supported by American Heart Association grant number 18CDA34110116. Julia Ramierz acknowledges support by the People Programme of the European Unionâs Seventh Framework Programme grant n° 608765 and Marie Sklodowska-Curie grant n° 786833. Maria Sabater-Lleal is supported by a Miguel Servet contract from the ISCIII Spanish Health Institute (CP17/00142) and co-financed by the European Social Fund. Jian Yang is funded by the Westlake Education Foundation. Olga Giannakopoulou has received funding from the British Heart Foundation (BHF) (FS/14/66/3129). CHARGE Consortium cohorts were supported by R01HL105756. Study-specific acknowledgements are available in the Additional file 32: Supplementary Note. The views expressed in this manuscript are those of the authors and do not necessarily represent the views of the National Heart, Lung, and Blood Institute; the National Institutes of Health; or the U.S. Department of Health and Human Services.Peer reviewedPublisher PD
Implicating genes, pleiotropy, and sexual dimorphism at blood lipid loci through multi-ancestry meta-analysis
Abstract Background Genetic variants within nearly 1000 loci are known to contribute to modulation of blood lipid levels. However, the biological pathways underlying these associations are frequently unknown, limiting understanding of these findings and hindering downstream translational efforts such as drug target discovery. Results To expand our understanding of the underlying biological pathways and mechanisms controlling blood lipid levels, we leverage a large multi-ancestry meta-analysis (Nâ=â1,654,960) of blood lipids to prioritize putative causal genes for 2286 lipid associations using six gene prediction approaches. Using phenome-wide association (PheWAS) scans, we identify relationships of genetically predicted lipid levels to other diseases and conditions. We confirm known pleiotropic associations with cardiovascular phenotypes and determine novel associations, notably with cholelithiasis risk. We perform sex-stratified GWAS meta-analysis of lipid levels and show that 3â5% of autosomal lipid-associated loci demonstrate sex-biased effects. Finally, we report 21 novel lipid loci identified on the X chromosome. Many of the sex-biased autosomal and X chromosome lipid loci show pleiotropic associations with sex hormones, emphasizing the role of hormone regulation in lipid metabolism. Conclusions Taken together, our findings provide insights into the biological mechanisms through which associated variants lead to altered lipid levels and potentially cardiovascular disease risk
Implicating genes, pleiotropy, and sexual dimorphism at blood lipid loci through multi-ancestry meta-analysis
Funding Information: GMP, PN, and CW are supported by NHLBI R01HL127564. GMP and PN are supported by R01HL142711. AG acknowledge support from the Wellcome Trust (201543/B/16/Z), European Union Seventh Framework Programme FP7/2007â2013 under grant agreement no. HEALTH-F2-2013â601456 (CVGenes@Target) & the TriPartite Immunometabolism Consortium [TrIC]-Novo Nordisk Foundationâs Grant number NNF15CC0018486. JMM is supported by American Diabetes Association Innovative and Clinical Translational Award 1â19-ICTS-068. SR was supported by the Academy of Finland Center of Excellence in Complex Disease Genetics (Grant No 312062), the Finnish Foundation for Cardiovascular Research, the Sigrid Juselius Foundation, and University of Helsinki HiLIFE Fellow and Grand Challenge grants. EW was supported by the Finnish innovation fund Sitra (EW) and Finska LĂ€karesĂ€llskapet. CNS was supported by American Heart Association Postdoctoral Fellowships 15POST24470131 and 17POST33650016. Charles N Rotimi is supported by Z01HG200362. Zhe Wang, Michael H Preuss, and Ruth JF Loos are supported by R01HL142302. NJT is a Wellcome Trust Investigator (202802/Z/16/Z), is the PI of the Avon Longitudinal Study of Parents and Children (MRC & WT 217065/Z/19/Z), is supported by the University of Bristol NIHR Biomedical Research Centre (BRC-1215â2001) and the MRC Integrative Epidemiology Unit (MC_UU_00011), and works within the CRUK Integrative Cancer Epidemiology Programme (C18281/A19169). Ruth E Mitchell is a member of the MRC Integrative Epidemiology Unit at the University of Bristol funded by the MRC (MC_UU_00011/1). Simon Haworth is supported by the UK National Institute for Health Research Academic Clinical Fellowship. Paul S. de Vries was supported by American Heart Association grant number 18CDA34110116. Julia Ramierz acknowledges support by the People Programme of the European Unionâs Seventh Framework Programme grant n° 608765 and Marie Sklodowska-Curie grant n° 786833. Maria Sabater-Lleal is supported by a Miguel Servet contract from the ISCIII Spanish Health Institute (CP17/00142) and co-financed by the European Social Fund. Jian Yang is funded by the Westlake Education Foundation. Olga Giannakopoulou has received funding from the British Heart Foundation (BHF) (FS/14/66/3129). CHARGE Consortium cohorts were supported by R01HL105756. Study-specific acknowledgements are available in the Additional file : Supplementary Note. The views expressed in this manuscript are those of the authors and do not necessarily represent the views of the National Heart, Lung, and Blood Institute; the National Institutes of Health; or the U.S. Department of Health and Human Services. Publisher Copyright: © 2022, The Author(s).Background: Genetic variants within nearly 1000 loci are known to contribute to modulation of blood lipid levels. However, the biological pathways underlying these associations are frequently unknown, limiting understanding of these findings and hindering downstream translational efforts such as drug target discovery. Results: To expand our understanding of the underlying biological pathways and mechanisms controlling blood lipid levels, we leverage a large multi-ancestry meta-analysis (N = 1,654,960) of blood lipids to prioritize putative causal genes for 2286 lipid associations using six gene prediction approaches. Using phenome-wide association (PheWAS) scans, we identify relationships of genetically predicted lipid levels to other diseases and conditions. We confirm known pleiotropic associations with cardiovascular phenotypes and determine novel associations, notably with cholelithiasis risk. We perform sex-stratified GWAS meta-analysis of lipid levels and show that 3â5% of autosomal lipid-associated loci demonstrate sex-biased effects. Finally, we report 21 novel lipid loci identified on the X chromosome. Many of the sex-biased autosomal and X chromosome lipid loci show pleiotropic associations with sex hormones, emphasizing the role of hormone regulation in lipid metabolism. Conclusions: Taken together, our findings provide insights into the biological mechanisms through which associated variants lead to altered lipid levels and potentially cardiovascular disease risk.Peer reviewe
Effect of angiotensin-converting enzyme inhibitor and angiotensin receptor blocker initiation on organ support-free days in patients hospitalized with COVID-19
IMPORTANCE Overactivation of the renin-angiotensin system (RAS) may contribute to poor clinical outcomes in patients with COVID-19.
Objective To determine whether angiotensin-converting enzyme (ACE) inhibitor or angiotensin receptor blocker (ARB) initiation improves outcomes in patients hospitalized for COVID-19.
DESIGN, SETTING, AND PARTICIPANTS In an ongoing, adaptive platform randomized clinical trial, 721 critically ill and 58 nonâcritically ill hospitalized adults were randomized to receive an RAS inhibitor or control between March 16, 2021, and February 25, 2022, at 69 sites in 7 countries (final follow-up on June 1, 2022).
INTERVENTIONS Patients were randomized to receive open-label initiation of an ACE inhibitor (nâ=â257), ARB (nâ=â248), ARB in combination with DMX-200 (a chemokine receptor-2 inhibitor; nâ=â10), or no RAS inhibitor (control; nâ=â264) for up to 10 days.
MAIN OUTCOMES AND MEASURES The primary outcome was organ supportâfree days, a composite of hospital survival and days alive without cardiovascular or respiratory organ support through 21 days. The primary analysis was a bayesian cumulative logistic model. Odds ratios (ORs) greater than 1 represent improved outcomes.
RESULTS On February 25, 2022, enrollment was discontinued due to safety concerns. Among 679 critically ill patients with available primary outcome data, the median age was 56 years and 239 participants (35.2%) were women. Median (IQR) organ supportâfree days among critically ill patients was 10 (â1 to 16) in the ACE inhibitor group (nâ=â231), 8 (â1 to 17) in the ARB group (nâ=â217), and 12 (0 to 17) in the control group (nâ=â231) (median adjusted odds ratios of 0.77 [95% bayesian credible interval, 0.58-1.06] for improvement for ACE inhibitor and 0.76 [95% credible interval, 0.56-1.05] for ARB compared with control). The posterior probabilities that ACE inhibitors and ARBs worsened organ supportâfree days compared with control were 94.9% and 95.4%, respectively. Hospital survival occurred in 166 of 231 critically ill participants (71.9%) in the ACE inhibitor group, 152 of 217 (70.0%) in the ARB group, and 182 of 231 (78.8%) in the control group (posterior probabilities that ACE inhibitor and ARB worsened hospital survival compared with control were 95.3% and 98.1%, respectively).
CONCLUSIONS AND RELEVANCE In this trial, among critically ill adults with COVID-19, initiation of an ACE inhibitor or ARB did not improve, and likely worsened, clinical outcomes.
TRIAL REGISTRATION ClinicalTrials.gov Identifier: NCT0273570
L'organisation des archives intermĂ©diaires : du wagon de tĂȘte au wagon de queue. ExpĂ©rience canadienne et quĂ©bĂ©coise et comparaison internationale
Carol Couture, Die Organisation der Zwischenarchive : vont ersten zum letzten Waggon. Erfahrungen in Kanada und Québec, sowie internationale Vergleiche.
Kanada â und insbesondere QuĂ©bec â vertreten eine integrierte Archivistik, die auf die KontinuitĂ t ihrer Interventionen achtet und zudem eine weitgefasste Politik der Archivorganisation verfolgt. Die Nationalarchive Kanadas und der Provinz QuĂ©bec, welche fĂŒr die Behandlung der Zwischenarchive zustĂ ndig sind, haben bewiesen, dass sie auf diese Weise deren Aufbewahrungskosten drastisch senken konnten. Eine Umfrage, die in 26 LĂ€ndern auf 5 Kontinenten durchgefiihrt wurde, hat aufgezeigt, dass dort das records management in der Regel schwĂ cher entwickelt ist ; jedoch konnte ein Konsens bezuglich einer erweiterten DĂ©finition des Begriffs «Archiv » erzielt werden, und dies auch im Sinne einer verstĂ€rkten Implizierung der Archivare.Carol Couture, Organizing semi-current records : from the front to the tail coach Canadian and QuĂ©bĂ©cois experience and international comparison.
Canada and particularly Quebec are promoting an integrated form of archives administration, that stresses continuity in management and accomplishes an organizational policy for archives in a broad meaning. The National Archives of Canada, and of Quebec received responsibility for managing semi-current records and succeeded in greatly reducing their conservation cost. A survey sent to 26 countries in all 5 continents demonstrated that records management was not in general very developed, but that a consensus favored an enlarged dĂ©finition of archives as well as an increasing involvement of archivists.Le Canada et singuliĂšrement le QuĂ©bec dĂ©fendent une archivistique intĂ©grĂ©e qui veille Ă la continuitĂ© de ses interventions et met en Ćuvre une politique d'organisation des archives entendues largement. Les Archives nationales du Canada comme celles du QuĂ©bec se sont fait attribuer la responsabilitĂ© de la gestion des archives intermĂ©diaires et ont dĂ©montrĂ© qu'elles parvenaient ainsi Ă rĂ©duire sensiblement le coĂ»t de leur conservation. Une enquĂȘte menĂ©e auprĂšs de 26 pays reprĂ©sentant les cinq continents a montrĂ© que le records management n'y Ă©tait pas, en rĂšgle gĂ©nĂ©rale, aussi dĂ©veloppĂ© mais qu'un consensus se dĂ©gageait autour d'une dĂ©finition Ă©largie des archives et d'une volontĂ© d'implication accrue des archivistes.Couture Carol. L'organisation des archives intermĂ©diaires : du wagon de tĂȘte au wagon de queue. ExpĂ©rience canadienne et quĂ©bĂ©coise et comparaison internationale. In: La Gazette des archives, n°170-171, 1995. Entre la gestion et la documentation historique de la recherche. Le prĂ©-archivage en France et Ă lâĂ©tranger : hier, aujourdâhui, demain (journĂ©e dâĂ©tudes de lâAAF, 27 janvier 1995) pp. 337-355
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